conclusions genome instability in addicted patients was demonstrated in this study. controversially, considering incoherent results of previous studies and our data, more studies in longer duration of methadone use are needed to elucidate the consequence. results the mutagenicity index in addicted group was robustly higher than healthy volunteers. fortunately, this significant difference was lo...

background the increasing use of herbal drugs and their easy availability have necessitated the use of mutagenicity tests to analyze their toxicity and safety. objectives the aim of this study was to determine the in vitro mutagenicity of artemisia draconculus l., a herbal drug, by performing single cell gel electrophoresis (scge). materials and methods in this study, we obtained a herbal drug ...

background: alpinia galanga l. belonging to the family zingiberaceae is widely grown in the state of kerala, india. they are effective antioxidant and free radical scavenger under both in vitro and in vivo condition. the efficacy of the isolated flavonoids in conferring protection from radiation induced damages to genomic dna was studied. materials and methods: the bioflavonoids, galangin and k...

background traditional medicines are among the oldest medicines and their extensive use in the recent years reflects the public’s interest in alternatives to conventional medicine. objectives the aim of this study was to investigate the genotoxicity of dillsun herbal medicine in dna damage of rat hepatocytes compared to sodium dichromate using a comet assay technique. materials and methods male...

use of different pesticides in the agriculture sector, in order to boost crop yield within a short time period and low labor, has been tremendously increased since the last decade. pesticide use has elevated crop yield but has produced a number of pronounced problems regarding environmental and health safety. the continuously deteriorating toxicological effects of these pesticides are not only ...

background apoptosis or programmed cell death is an essential process for elimination of damaged cells. also, induction of apoptosis is fundamental for treating cancer. screening for agents that induce apoptosis in tumor cells help in the development of novel agents for cancer treatment. numerous studies suggest that the exposure of tumor cells to statins can lead to cell death via two separate...

normal 0 false false false en-us x-none ar-sa microsoftinternetexplorer4 background : cotoneaster discolor and alhagi pseudalhagi are two important kinds of iranian manna.   they have several therapeutic applications in adults and children. the most important ingredient of cotoneaster discolor is mannitol. due to the scarcity of toxicological studies on these compounds, their genotoxicity was e...

abstractbackground: radioprotective effects of famotidine, an antagonist of h2 receptor clinically used for peptic ulcer treatment, was previously shown on radiation-induced micronuclei and chromosomal aberration in human peripheral blood lymphocytes and mouse bone marrow cells. this study was conducted to investigate radioprotective property of famotidine against radiation induced apoptosis in...

background the increasing use of herbal drugs and their ease of accessibility and availability have necessitated the use of mutagenicity test to analyze their toxicity and safety. objectives this study aimed to evaluate the genotoxicity of sankol herbal medicine in dna breakage of rat hepatocytes in comparison with h2o2 by single cell gel electrophoresis technique or comet assay. materials and ...

Objective(s): Precision-cut tissue slices are considered an organotypic 3D model widely used in biomedical research. The comet assay is an important screening test for early genotoxicity risk assessment that is mainly applied on in vitro models.  The aim of the present study was to provide a 3D organ system for determination of genotoxicity using a modified method of the comet assay since the s...